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Schneider, Christine L., PhD

Assistant Professor
Office: Rankin B01
Office Phone: 262-524-7278
B.S. – Biochemistry, University of Wisconsin Madison 1989
B.S. – Molecular Biology, University of Wisconsin Madison 1989

M.S. – Biology and Microbiology, University of Wisconsin Oshkosh 2002
Ph. D. – Microbiology and Molecular Genetics, Medical College of Wisconsin 2011
Areas of Specialization:
Immune evasion strategies of human herpesviruses, microbiology, virology, immunology, genetics, and cell biology.
Scholarly and Professional Achievements:
Mellergaard M, Skovbakke SL, Schneider CL, Lauridsen F, Andresen L, Jensen H, Skov S. N-glycosylation of asparagine N8 regulates surface expression of MHC class I chain-related protein A (MICA) alleles dependent on threonine T24. J Biol Chem. 2014 May 28. pii: jbc.M114.573238.

Schneider, CL, Hudson, AW. The Human Herpesvirus-7 (HHV-7) U21 immunoevasin subverts NK-mediated Cytotoxicity through modulation of MICA and MICB.  PLoS pathog. 2011 Nov; 7(11):e1002362

Glosson NL, Gonyo P, May NA, Schneider CL, Ristow LC, Wang Q, Hudson AW. Insight into the mechanism of HHV-7 U21-mediated diversion of class I MHC molecules to lysosomes. J Biol Chem. 2010 Nov 19;285(47):37016-29.

LaCount DJ, Hanson SF, Schneider CL, Friesen PD.  Caspase inhibitor P35 and inhibitor of apoptosis Op-IAP block in vivo proteolytic activation of an effector caspase at different steps.  J Biol Chem. 2000 May 26;275(21):15657-64.

Fisher AJ, Cruz W, Zoog SJ, Schneider CL, Friesen PD.  Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition. EMBO J. 1999 Apr 15;18(8):2031-9.

Staszewski S, Massari FE, Kober A, Göhler R, Durr S, Anderson KW, Schneider CL, Waterbury JA, Bakshi KK, Taylor VI, et al. Combination therapy with zidovudine prevents selection of human immunodeficiency virus type 1 variants expressing high-level resistance to L-697,661, a nonnucleoside reverse transcriptase inhibitor.  J Infect Dis. 1995 May;171(5):1159-65.

Byrnes VW, Emini EA, Schleif WA, Condra JH, Schneider CL, Long WJ, Wolfgang JA, Graham DJ, Gotlib L, Schlabach AJ, et al.  Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitors. Antimicrob Agents Chemother. 1994 Jun;38(6):1404-7.

Schleif WA, Murthy KK, Sardana VV, Schneider CL, Byrnes VW, Cobb KE, Roth E, Wolfgang JA, Hoffman JM, Smith AM, et al.  Attempted prophylaxis of human immunodeficiency virus type 1 infection in chimpanzees with a nonnucleoside reverse transcriptase inhibitor. AIDS Res Hum Retroviruses. 1994 Jan;10(1):107-10.

Byrnes VW, Sardana VV, Schleif WA, Condra JH, Waterbury JA, Wolfgang JA, Long  WJ, Schneider CL, Schlabach AJ, Wolanski BS, et al.  Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors.  Antimicrob Agents Chemother. 1993 Aug;37(8):1576-9.

LaFemina RL, Schneider CL, Robbins HL, Callahan PL, LeGrow K, Roth E, Schleif  WA, Emini EA. Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells. J Virol. 1992 Dec;66(12):7414-9.

Manam S, Shinder GA, Joslyn DJ, Kraynak AR, Hammermeister CL, Leander KR, Ledwith BJ, Prahalada S, van Zwieten MJ, Nichols WW. Dose-related changes in the profile of ras mutations in chemically induced CD-1 mouse liver tumors. Carcinogenesis. 1995 May;16(5):1113-9.

Takagi H, Sharp R, Hammermeister C, Goodrow T, Bradley MO, Fausto N, Merlino G. Molecular and genetic analysis of liver oncogenesis in transforming growth factor alpha transgenic mice. Cancer Res. 1992 Oct 1;52(19):5171-7.

Manam S, Storer RD, Prahalada S, Leander KR, Kraynak AR, Hammermeister CL, Joslyn DJ, Ledwith BJ, van Zwieten MJ, Bradley MO, et al.  Activation of the Ki-ras gene in spontaneous and chemically induced lung tumors in CD-1 mice. Mol Carcinog. 1992;6(1):68-75.

Posters and Presentations:

Schneider, CL, Hudson, AW. Presentation: HHV-7 U21 is a multifunctional immunoevasin that disrupts the trafficking of NK activating ligands in addition to class I MHC.  Betaherpesviruses satellite session at the 36th annual International Herpesvirus Workshop 2010 conference, Salt Lake City, UT.

Schneider, CL, Hudson, AW. Presentation: The HHV-7 Immunoevasin U21 Directs ULBP1 to Lysosomes.  3rd Annual Center for Human Immunology Symposium, Milwaukee, WI. “Outstanding Abstract” awardee.

Schneider, CL, Hudson, AW.  Poster: Characterization of the HHV-6B U20 open reading frame.  12th annual International Cytomegalovirus/Betaherpesvirus workshop 2009, Boston, MA.

Schneider, CL, Hudson, AW.  Presentation: Characterization of the HHV-6 and HHV-7 U20 open reading frames.  International conference on HHV-6 & 7, Baltimore, MD.
Honors and Awards:
STAR scholar grant for student-faculty research (2013)

Last updated 7/17/2014

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